1/5

Lab-on-a-disc

The FRUITS group has strong interests and unique capability in development of ”Fully Integrated Lab-on-a-disc” for liquid biopsy applications such as CTC, EV and cfDNA as well as various kinds of applications such as blood analysis, immunoassay, pathogen detection, molecular diagnostics, water quality analysis etc.

We plan to further investigate to achieve in-depth understanding of the centrifugal microfluidic phenomena as well as to combine non-conventional force field on the spinning disc while continuing developing high-impact total analysis system.

Liquid biopsy

- Extracellular Vesicles

- Circulating Tumor Cells

- Circulating Tumor DNA/Cell-free DNA

References

 

• Analytical Chemistry, 89, 1155-1162 (2017)

• ACS Nano, 11, 1360-1370 (2017) 

• Lab on a Chip, 18, 1320-1329 (2018) Part of the themed collection: Personalised Medicine: Liquid Biopsy

Centrifugal Microfluidics

- Valve implementation on a disc

- Blood separation

- Paper on a disc

- Blood separation

References

 

• Lab on a Chip, 16, 3741-3749 (2016)

• Sensors & Actuators: B. Chemical, 178, 648-655 (2013) 

• Lab on a Chip, 11, 3404-3406 (2011), Top 10 the most accessed articles in Aug. and in Sep. 2011. 

• Lab on a Chip,  11, 1434 - 1436 (2011) Top 10 the most accessed articles in Mar. 2011. 

Biomedical diagnostics

- Virus DNA Extraction 

from Whole Blood

- Simultaneous Biochemistry and      immunoassay Analyses

-Electrochemical Immunosensor

- Pathogen specific DNA extraction

 from whole blood on a CD

- Fully Integrated Multiplex Immunoassay from Whole Blood

References


• Analytical Chemistry, 86, 3841–3848 (2014)

• Lab on a Chip, 13, 3747-3754 (2013) 

• Analytical Chemistry, 84, 2133–2140 (2012)

• Lab on a Chip, 11, 70-78 (2011) Cover story. 

• Lab on a Chip, 1758-1773, (2010) Top 10 accessed on the web in July 2010 

• Lab on a Chip, 9, 1548-1555  (2009) Top 10 accessed on the web in May 2009 

• Lab on a Chip, 7, 565-573 (2007) Cover story. 

Food, Environment, and Energy Applications

- Antioxidant analysis from beverage

- Microalgal lipids quantification 

- Nutrients Analysis from sea water

- Caffeine sensor on a disc

- Molecular Diagnostics for Food-borne

pathogen detection

 

References

• Lab on a Chip, 16, 3268-3275 (2016)

• Analytical Chemistry, 87, 7865-7871 (2015)

• Analytical Chemistry, 86, 3841–3848 (2014) C&EN (Chemical & Engineering News),"A Spinning Disc Spots Spoiled Food“

• Analytical Chemistry, 85, 2954–2960 (2013) 

• Scientific Reports, 3, 2255 (2013)