We report the surface modification of thermoplastic nanochannels and an assessment of the associated surface charge density, zeta potential and electroosmotic flow (EOF). Carboxylated PMMA nanochannels were efficient for the transport and elongation of λ-DNA while these same DNA molecules were unable to translocate through aminated nanochannels with lower surface charge density and zeta potential.

In this paper, we propose a centrifugal-force-based size-selective CTC isolation platform that can isolate and enumerate CTCs from whole blood within 30 s with high purity. Overall, our CTC isolation device enables rapid and label-free isolation of CTCs with high purity, which should greatly improve downstream molecular analyses of captured CTCs.

This paper demonstrates the first semiconductor-based nanofiber sensor suspended on carbon electrodes that has achieved by a relatively simple and cost-effective electrospinning method. Furthermore, these sensors demonstrate a high sensitivity, as well as a stable ohmic contact, due to the large surface area of the TiO2 NWs and the carbon-carbon contact between the suspended TiO2/C NFs and carbon electrodes.

This paper demonstrates that molecular detection of food-borne pathogens can be integrated into a single, compact device with great potential as a point of care diagnostic tool. Three main functions, DNA extraction, isothermal recombinase polymerase amplification (RPA), and detection, are integrated on a single device for the molecular detection of Salmonella.

Roles of small GTPases in lysophosphatidic acid-induced chemotaxis of SKOV3 ovarian cancer cells were first investigated using a novel microfluidic assay platform. Real-time tracking of individual cells in the rapid-prototyped multilevel microfluidic devices provided us substantial quantitative information about the chemotaxis of the cells under a linear and stable concentration gradient. This integrative study of cellular chemotaxis would provide us new biological insights, which could not be obtained through the traditional tools for cell migration assays.

Aqueous reagent solution micro-domains with sharp boundaries and defined shapes are created over cell monolayers within an immiscible bulk aqueous phase through rehydration of freestanding and portable dried reagent patches of the corresponding shape....

The molecular mechanism of the interaction between silane, e.g. APTES, with the plasma activated thermoplastic surfaces was investigated. The effect of the type of solvent during the silane deposition step on the thickness, surface morphology, stability and chemical properties of the APTES layer on plasma treated thermoplastics was explored.

We report a novel aqueous phase fluorescent caffeine sensor named Caffeine Orange which exhibits 250-fold fluorescence enhancement upon caffeine activation and high selectivity. To utilize this probe in real life, we developed a microfluidic device to make caffeine detection quick, sensitive and automated.

In this review, we summarize recent advances in pumping techniques for microfluidic cell culture and discuss their advantages and possible drawbacks.

We present a novel fullyintegrated centrifugal microfluidic devicewith features for target antigen capture from biological samples, via a bead-based enzyme-linkedimmune-sorbent assay, and flow-enhanced electrochemicaldetection.

We demonstrate that electrochemical velocimetry is a straightforward technique to accurately monitor flow on rotating microfluidic platforms in real-time.

We introduce a new fully integrated centrifugal microfluidic device for simultaneous determination of five major inorganic nutrients: nitrite, nitrate+nitrite, ammonium, orthophosphate, and silicate.

This paper describes a system to study how small physical perturbations can affect bacterial community behavior in unexpected ways through modulation of diffusion and convective transport of chemical communication molecules and resources

The geometric factors for faster particle separation rate on a centrifugal microfluidic platform are described

This report presents a multilevel microfluidic platform for robust construction of hydrogel scaffold in microchannels and its application to three dimensional (3D) multicellular co-cultures and assays.

A possible mechanism for the aminosilane-mediated room-temperature (RT) bonding of thermoplastics and poly(dimethylsiloxane) (PDMS) is presented.

We report a versatile method for bonding dissimilar materials which is an important issue in the fabrication of micro- and nanofluidic devices.

We describe patterning of bacterial biofilms using polymer-based aqueous two-phase system (ATPS) microprinting protocols.

This paper presents a cost-effective, rapid, and fully automated lab-on-a-disc for simultaneous detection of multiple protein biomarkers in raw samples such as whole blood or whole saliva.

Single suspended carbon nanowires (CNWs) integrated on carbon-MEMS (CMEMS) structures are fabricated by electrospinning of SU-8 photoresist followed by pyrolysis.